Education / Publications

Aerogen Publications

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Investigation of the Quantity of Exhaled Aerosols Released into the Environment during Nebulisation

McGrath JA, O’Sullivan A, Bennett G, et al. Pharmaceutics.

In this month's Clinical Spotlight: McGrath et al. found that a vibrating mesh nebulizer used with a mouthpiece and filter minimized the risk of exhaled medical aerosol emissions compared to baseline. (McGrath et al. 2019)

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Nasal High-Flow Bronchodilator Nebulization: A Randomized Cross-Over Study

Reminiac F, Vecellio L, Bodet-Contentin L, et al. Ann Intensive Care. 2018 Dec 20;8(1):128

Albuterol vibrating mesh nebulization within a nasal high-flow circuit induces similar bronchodilation to standard facial mask jet nebulization.

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Comparison of bronchodilator administration with vibrating mesh nebulizer and standard jet nebulizer in the emergency department

Dunne RB and Shortt S. Am J Emerg Med. 2018 Apr;36(4):641-646.

In this month's Clinical Spotlight: Dunne et al. showed that 85% of patients treated with a vibrating mesh nebulizer achieved symptom control with a single bronchodilator dose. (Dunne & Shorrt)

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Clinical efficacy of vibrating mesh and jet nebulizers with different interfaces in pediatric subjects with asthma

Moody GB, Luckett PM, Shockley CM, et al.

In this month's Clinical Spotlight: Moody et al. studies the clinical outcomes following bronchodilator delivery via the Aerogen® Ultra Versus a jet nebuliser in children presenting to the Emergency Department with acute moderate-to-severe asthma (Moody et al. 2020)

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Impact of Gas Flow and Humidity on Trans-Nasal Aerosol Deposition via Nasal Cannula in Adults: A Randomized Cross-Over Study

Alcoforado L, Ari A, Barcelar JM, et al. Pharmaceutics. 2019 Jul 7;11(7):320.

A lung dose of 17.2 % is achievable at a flow rate of 10 L/min. Lower flow rates correlate with higher lung drug deposition.

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Aerosol delivery with two ventilation modes during mechanical ventilation: A randomized study

Dugernier J, Reychler G, Wittebole X, et al. Ann Intensive Care. 2016 Dec;6(1):73

In this months clinical spotlight: Dugernier et al. compares lung deposition of a radiolabeled aerosol generated with a vibrating-mesh nebulizer during invasive mechanical ventilation, with two modes: pressure support

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SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study

Dugernier J, Hesse M, Vanbever R, et al. Pharm Res. 2017 Feb;34(2):290-300. 

Lung dose was six times higher with the Ultra (34.1%) vs Jet Neb (5.2%)

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Radioaerosol Pulmonary Deposition Using Mesh and Jet Nebulizers During Noninvasive Ventilation in Healthy Subjects

Galindo-Filho VC, Ramos ME, Rattes CS, et al.  Respir Care. 2015 Sep;60(9):1238-46.

In this month's Clinical Spotlight: An imaging study by Galindo-Filho et al. reported significantly greater aerosol delivery to the lungs with vibrating mesh during non-invasive ventilation as compared with a jet nebulizer, in healthy adults. (Galindo-Filho et al.)

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Dose Response to Transnasal Pulmonary Administration of Bronchodilator Aerosols via Nasal High-Flow Therapy in Adults with Stable Chronic Obstructive Pulmonary Disease and Asthma

Li J, Zhao M, Hadeer M, et al.  Respiration. 2019;98(5):401-409

In this month's Clinical Spotlight: Li et al. showed that bronchodilator delivery via vibrating mesh inline during high flow nasal cannula results in a positive bronchodilator response in patients with stable asthma and COPD.(Li et al.)

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Worldwide Clinical Practice of High-Flow Nasal Cannula and Concomitant Aerosol Therapy in the Adult ICU Setting

Li J, Tu M, Yang L, et al.  Respir Care. 2021 Sep;66(9):1416-1424

In this months clinical spotlight: Li et al. aims to provide insight into the practical implementation of HFNC and how to provide aerosol delivery during HFNC therapy in adult patients.

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Efficiency of Different Aerosol Devices and Masks during Noninvasive Positive Pressure Ventilation in a Simulated Adult Lung Model

AlQuaimi MM, Fink JB and Ari A.  J Respir Med Lung Dis. 2017; 2(3): 1018.

In this month's Clinical Spotlight, AlQuaimi et al evaluated the drug delivery efficiency of the Aerogen Solo versus a jet nebuliser and a pMDI in a simulated adult lung model using different non-invasive ventilation facemasks

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Comparison of Vibrating Mesh and Jet Nebulizers During Noninvasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Avdeev SN, Nuralieva GS, Soe AK, et al. J Aerosol Med Pulm Drug Deliv. 2021 Dec;34(6):358-365.

In this month's Clinical Spotlight: Avdeev and colleagues showed that patients on non-invasive ventilation treated with albuterol delivered by vibrating mesh displayed improved lung function and symptom scores, as compared with a jet nebulizer. (Avdeev et al.)

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Bronchodilator Delivery via High-Flow Nasal Cannula: A Randomized Controlled Trial to Compare the Effects of Gas Flows

Li J, Chen Y, Ehrmann S, et al. Pharmaceutics. 2021 Oct 11;13(10):1655

In this month's Clinical Spotlight, Li et al investigated the effect of high-flow on response to aerosolised bronchodilator therapy delivered using the Aerogen Solo in patients with asthma or COPD. (Li et al.)